Metabolic pathway dysregulation in diffuse axonal injury: a multimodal biomarker approach for early diagnosis and mechanistic insights
DAI involves systemic metabolic network dysfunction centered on mitochondrial energetics and lipid metabolism. Pathway-centric biomarkers enhance diagnostic precision and prognostication, offering a novel framework for biomarker-driven management of TBI. These findings highlight mitochondrial FAO and phospholipid homeostasis as potential therapeutic targets, addressing a critical gap in DAI care.
Authors
- Cong Xu (ORCID: https://orcid.org/0000-0002-7467-2083)
- Chunyu Yao
- Shengwen Calvin Li (ORCID: https://orcid.org/0000-0002-9699-9204)
- Kaijie Sun
- Guanjun Wang (ORCID: https://orcid.org/0009-0004-8272-7808)
- Wen Su (ORCID: https://orcid.org/0000-0003-0604-7603)
- Lisheng Xu (ORCID: https://orcid.org/0000-0001-8360-3605)
- Taotao Zhang (ORCID: https://orcid.org/0000-0003-0826-3254)
- Wei‐Liang Chen (ORCID: https://orcid.org/0000-0003-4941-6130)
Institutions
- First People's Hospital of Nanning (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fneur.2025.1677730
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Medical Association
- Medical and Health Research Project of Zhejiang Province