Severe and/or prolonged COVID-19 in hematologic diseases: clinical implications before and during the omicron era
In patients with hematologic diseases, the Omicron period was associated with reduced severity and COVID-19-related mortality but no improvement in OS. Older age and prior bendamustine exposure were strongly associated with adverse outcomes, highlighting the need for strict infection prevention and prompt, aggressive COVID-19 management in these high-risk populations.
Authors
- Keichiro Mihara (ORCID: https://orcid.org/0000-0002-6051-7517)
- Chisako Iriyama
- Akinao Okamoto (ORCID: https://orcid.org/0000-0002-9607-8536)
- Takahide Ara (ORCID: https://orcid.org/0000-0001-9609-3202)
- Tomohiro Kajiguchi
- Daisuke Ikeda (ORCID: https://orcid.org/0000-0002-7398-4616)
- Takahiro Nishiyama (ORCID: https://orcid.org/0000-0002-6445-7697)
- Yoshihiro Inamoto
- Shingo Kurahashi
- Hiroki Hosoi (ORCID: https://orcid.org/0000-0002-8682-7476)
- Hideyuki Yamamoto (ORCID: https://orcid.org/0000-0001-6231-5954)
- Akihiro Tomita (ORCID: https://orcid.org/0000-0002-5391-1399)
- Junji Hiraga (ORCID: https://orcid.org/0000-0002-1845-4786)
- Yoshiko Atsuta (ORCID: https://orcid.org/0000-0003-4404-2870)
- Eisei Kondo
- Tomohiro Horio (ORCID: https://orcid.org/0000-0002-3485-6857)
- Yoshiaki Marumo (ORCID: https://orcid.org/0009-0003-6326-4994)
- Hitomi Sawa
- Takahiko Miyama (ORCID: https://orcid.org/0000-0002-3028-4521)
- Yasufumi Masaki (ORCID: https://orcid.org/0000-0002-5658-3765)
- Senji Kasahara (ORCID: https://orcid.org/0000-0002-1784-2402)
- Shun‐ichi Kimura (ORCID: https://orcid.org/0000-0001-9827-8526)
- Takanobu Morishita (ORCID: https://orcid.org/0000-0002-0841-270X)
- Masahiro Yoshida (ORCID: https://orcid.org/0000-0002-3521-5322)
- Tatsuo Oyake (ORCID: https://orcid.org/0000-0002-8457-2211)
- Minoru Kanaya (ORCID: https://orcid.org/0000-0002-0035-8657)
- Yasuhiro Suzuki
- Shigeki Saito
- Kazutaka Ozeki
- Naoe Goto
Institutions
- Kanazawa University (JP)
- Fujita Health University (JP)
- Jichi Medical University (JP)
- Aichi Medical University (JP)
- Kanazawa Medical University (JP)
- Iwate Medical University (JP)
- Kawasaki Medical School (JP)
- Wakayama Medical University (JP)
- Nagoya City University (JP)
- Konan Kosei Hospital (JP)
- Kanazawa Medical Center (JP)
- Osaka City General Hospital (JP)
- Gifu Municipal Hospital (JP)
- Center for Cancer and Blood Disorders (US)
- Ichinomiya Municipal City Hospital (JP)
- Kameda Medical Center (JP)
- Nagoya City University Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Hokkaido University Hospital (JP)
- Toyota Kosei Hospital (JP)
- Anjo Kosei Hospital (JP)
- Toyohashi Municipal Hospital (JP)
- Nagoya Medical Center (JP)
- Japanese Red Cross Nagoya Daini Hospital (JP)
- The Japanese Data Center for Hematopoietic Cell Transplantation (JP)
- Tosei General Hospital (JP)
- Jichi Medical University Saitama Medical Center (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fonc.2025.1687204
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00