GINS2 promotes oral squamous cell carcinoma progression and immune evasion by recruiting PD-L1+ neutrophils and modulating the PTP4A1/PKM2 axis
GINS2 acts as a key oncogenic driver in OSCC, promoting tumor progression and facilitating immune evasion. Its effects appear to involve a proximal GINS2-PTP4A1-PKM2 module and the recruitment/polarization of PD-L1<sup>+</sup> neutrophils linked to T-cell dysfunction. Targeting the GINS2 axis-potentially in combination with PD-L1 blockade-warrants further investigation in OSCC, with downstream signaling mechanisms to be clarified in future work.
Authors
- Bo Wei (ORCID: https://orcid.org/0000-0001-7386-2689)
- Hui Sun (ORCID: https://orcid.org/0000-0001-8348-4933)
- Jiajia Yin
- Bing Liu (ORCID: https://orcid.org/0000-0001-5302-0900)
- Peng Chen (ORCID: https://orcid.org/0009-0005-6217-0376)
- Chuyan Shi
Institutions
- Chinese PLA General Hospital (CN)
- Air Force General Hospital PLA (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1637296
- Citations
- 1
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.81