Cross-linked carboxyl-terminal telopeptide of type I collagen – A classic marker for bone resorption

Periodontitis is a common periodontal disease encountered worldwide; it is a chronic inflammatory condition that eventually leads to the destruction of supporting periodontal structures. Periodontal biomarkers are authentically important for assessing the activity of the disease and its treatment outcomes. Cross-linked carboxyl-terminal telopeptide of type I collagen (ICTP) represents one member of a significant group of molecules that are largely associated with bone resorptive diseases. Gingival inflammation can be distinguished from progressive periodontitis when ICTP can be applied clinically, as it is an existing biomarker specific to bone degradation. The present review article elaborates the role of ICTP as an implicit bio marker in estimating periodontal health and disease.