Efficacy of Enfortumab Vedotin After Platinum Chemotherapy and Pembrolizumab in Metastatic Urothelial Carcinoma: A Multicenter Real-World Analysis of the ARON-2EV Cohort
The ARON-2EV project is collecting real-world data for patients with metastatic cancer of the urinary tract who are being treated with a drug called enfortumab vedotin (EV) in multiple centers worldwide. Our results show that EV has consistent efficacy in these patients after previous treatment with platinum-based chemotherapy followed by pembrolizumab. The results also suggest an association between a patient's response to pembrolizumab and their subsequent response to EV.
Authors
- Tarek Taha (ORCID: https://orcid.org/0000-0001-7936-5245)
- Ondřej Fiala (ORCID: https://orcid.org/0000-0002-4096-7385)
- Zin Myint (ORCID: https://orcid.org/0000-0002-3479-4203)
- Andrey Coatrini Soares (ORCID: https://orcid.org/0000-0003-4601-3555)
- Sebastiano Buti (ORCID: https://orcid.org/0000-0003-0876-0226)
- Shilpa Gupta (ORCID: https://orcid.org/0000-0002-8775-503X)
- Matteo Santoni (ORCID: https://orcid.org/0000-0001-7340-6173)
- Akihiro Yano (ORCID: https://orcid.org/0000-0001-8453-2474)
- Thomas Büttner (ORCID: https://orcid.org/0000-0003-0316-9621)
- Giuseppe Luigi Banna (ORCID: https://orcid.org/0000-0003-0764-3650)
- Ravindran Kanesvaran (ORCID: https://orcid.org/0000-0002-2351-881X)
- Enrique Grande (ORCID: https://orcid.org/0000-0002-0134-4732)
- Vincenza Conteduca (ORCID: https://orcid.org/0000-0002-6921-714X)
- Jindřich Kopecký (ORCID: https://orcid.org/0000-0002-4126-0410)
- Michele Maffezzoli (ORCID: https://orcid.org/0000-0001-7877-8988)
- Luigi Formisano (ORCID: https://orcid.org/0000-0001-7205-5105)
- Lorena Incorvaia (ORCID: https://orcid.org/0000-0002-1199-7286)
- Francesco Massari (ORCID: https://orcid.org/0000-0001-6476-6871)
- Alfonso Gómez de Liaño (ORCID: https://orcid.org/0000-0002-1844-8474)
- Cecilia Nasso (ORCID: https://orcid.org/0000-0003-1261-2269)
- Gaetano Facchini (ORCID: https://orcid.org/0000-0002-7430-001X)
- Alexandr Poprach (ORCID: https://orcid.org/0000-0003-4698-9195)
- Fernando Sabino Marques Monteiro (ORCID: https://orcid.org/0000-0002-6621-8251)
- Kazutoshi Fujita (ORCID: https://orcid.org/0000-0002-6774-7497)
- Francesco Grillone (ORCID: https://orcid.org/0009-0009-6010-7604)
- Enrico Sammarco (ORCID: https://orcid.org/0000-0002-1390-918X)
- Joaquim Bellmunt (ORCID: https://orcid.org/0000-0003-2328-3421)
- Aruni Ghose (ORCID: https://orcid.org/0000-0001-8332-8033)
- Hana Študentová (ORCID: https://orcid.org/0000-0003-2105-9258)
- Patrizia Giannatempo (ORCID: https://orcid.org/0000-0002-3358-4466)
- Augusto Mota
- Alina Pirshtuk
Institutions
- University of Foggia (IT)
- University of Parma (IT)
- Cleveland Clinic (US)
- Royal Marsden NHS Foundation Trust (GB)
- Harvard University (US)
- Charles University (CZ)
- Masaryk University (CZ)
- Barts Health NHS Trust (GB)
- University Hospital Bonn (DE)
- Hospital Israelita Albert Einstein (BR)
- Markey Cancer Center (US)
- Portsmouth Hospitals NHS Trust (GB)
- Kindai University Hospital (JP)
- University Hospital in Motol (CZ)
- Masaryk Memorial Cancer Institute (CZ)
- Ospedale Santa Maria (IT)
- Federico II University Hospital (IT)
- Dana-Farber Cancer Institute (US)
- Azienda USL di Bologna (IT)
- Hospital Materno-Infantil (ES)
- National Cancer Centre Singapore (SG)
- University Hospital Hradec Králové (CZ)
- Azienda Ospedaliera Pugliese Ciaccio (IT)
- Ospedale di Livorno (IT)
- Hospital Sírio-Libanês (BR)
- Sociedade Brasileira de Oncologia Clínica (BR)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Social Insurance Saitama Chuo Hospital (JP)
- MD Anderson Cancer Center Madrid (ES)
- Ospedale Santa Corona (IT)
- Ospedale di Macerata
- University of Macerata (IT)
- University of Portsmouth (GB)
- Palacký University Olomouc (CZ)
- Saitama Medical University (JP)
- University of Palermo (IT)
- Kindai University (JP)
- University of Bologna (IT)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.euros.2025.10.010
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00