Toward Customization of Pickering Emulsion Nanocarriers for Personalized Delivery of Therapeutics in Cancer Treatments: A Review

The rapid advancement in nanotechnology over the past three decades has accelerated the development of novel and more potent cancer treatments. In particular, this has led to the development of an increasing number of novel carrier systems for drug delivery, among which Pickering emulsions are a strong contender. This article reviews the development, characterization, and therapeutic efficacy of Pickering emulsion nanocarriers designed specifically for cancer treatment. This approach offers significant benefits for overcoming many of the challenges experienced in conventional drug delivery systems for cancer therapy. The mechanisms of drug release, targeting strategies, and the stability of Pickering emulsions under physiological conditions are examined, along with an evaluation of their therapeutic potential and biocompatibility of these nanocarriers in various cancer models with in vitro and in vivo studies. The ability of Pickering emulsions to improve therapeutic efficacy through encapsulation and protection of hydrophobic drugs is also highlighted, resulting in targeted drug release at the tumor site and minimal side effects. Future development of the nanocarrier systems must address the challenges of achieving large‐scale production, regulatory approval, and translational application. If successfully addressed, it will pave the way for making personalized delivery of therapeutics for cancer treatment a reality.