Assessing liver-brain-muscle axis fatigability: five-run Stroop EncephalApp testing strengthens the association between covert hepatic encephalopathy and frailty
Advanced liver disease often features both covert hepatic encephalopathy (CHE) and frailty. In 194 patients, CHE diagnosed via QuickStroop (QSt) was associated with higher Liver Frailty Index (LFI). QSt and LFI showed a weak correlation (rho = 0.311), while the full Stroop test revealed a stronger correlation (rho = 0.455). These findings suggest that LFI may indirectly reflect psychomotor slowing and fatigability, which are better captured through full Stroop testing.
Authors
- Pamela M. Bloomer
- Miguel Sogbe (ORCID: https://orcid.org/0000-0002-2846-7812)
- Michael P. Dybala
- Randi Wong (ORCID: https://orcid.org/0000-0001-6210-7784)
- Alexandra Steinberg (ORCID: https://orcid.org/0009-0002-9548-509X)
- Jennifer C. Lai (ORCID: https://orcid.org/0000-0003-2092-6380)
- Andrés Duarte‐Rojo (ORCID: https://orcid.org/0000-0002-5377-9295)
- Robert S. Rahimi (ORCID: https://orcid.org/0000-0002-2595-1852)
Institutions
- Northwestern University (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Baylor University Medical Center (US)
- Clinica Universidad de Navarra (ES)
- Axcella Health (United States) (US)
Publication Details
- Journal
- npj gut and liver.
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1038/s44355-025-00039-7
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00