Febuxostat attenuates cyclophosphamide-induced ovarian toxicity; role of TLR4/NFκB/NLRP3 signaling pathway in female wistar albino rats
By controlling the TLR4/NF-Κb/NLRP3 signaling pathway, FEB has strong mitigating effects against oxidative stress, inflammatory processes, and apoptosis that result from CP-induced ovarian toxicity.
Authors
- Rabeh Khairy Saleh (ORCID: https://orcid.org/0009-0007-6979-838X)
- Sameh Reda (ORCID: https://orcid.org/0000-0003-4782-1773)
- Asmaa Taghian
- Asmaa Mohamed Abdel‐Aziz (ORCID: https://orcid.org/0000-0002-6184-2901)
- Samar Hisham Elsayed
- Walaa Yehia Abdelzaher (ORCID: https://orcid.org/0000-0001-6511-1797)
- Hanaa Mohamed Khalaf (ORCID: https://orcid.org/0000-0003-2102-1671)
- Marwa Hassan (ORCID: https://orcid.org/0009-0001-5129-6361)
- Alaa Mohamed (ORCID: https://orcid.org/0000-0001-5193-3319)
- Medhat Atta
- Mohamed Hassan M Abd Elghfar (ORCID: https://orcid.org/0009-0006-4022-1256)
Institutions
- Lotus Clinical Research (US)
- Minia University (EG)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/08923973.2025.2583496
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00