An Unusual Cause of Pulmonary Nodules

We report a rare case of pulmonary Kaposi’s sarcoma (KS) in a 63-year-old lung transplant recipient presenting with progressive respiratory decline. Initially suspected to have CMV pneumonitis or invasive fungal infection, diagnostic workup revealed pulmonary KS without cutaneous involvement. Despite antifungal and antiviral treatment, the patient’s condition worsened, leading to death. This case highlights the importance of considering neoplastic causes, including KS, in transplant patients with non-resolving pulmonary infiltrates, particularly in the context of prolonged immunosuppression.

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Publication Details

Journal
Open Respiratory Archives
Published
2025-11-05
DOI
https://doi.org/10.1016/j.opresp.2025.100510
Primary Topic
Viral-associated cancers and disorders
Type
article
Field-Weighted Citation Impact
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An Unusual Cause of Pulmonary Nodules

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An Unusual Cause of Pulmonary Nodules

Alicia de Pablo Gafas, Juan Margallo Iribarnegaray, María Teresa Tejedor Ortiz, Rodrigo Alonso Moralejo, Lucía Ortega Ruiz, Ana Belén Enguita Valls, Carlos Andrés Quezada Loaiza, Begoña Peña Del Cura, Clara Seghers Carreras
article en

Abstract

We report a rare case of pulmonary Kaposi’s sarcoma (KS) in a 63-year-old lung transplant recipient presenting with progressive respiratory decline. Initially suspected to have CMV pneumonitis or invasive fungal infection, diagnostic workup revealed pulmonary KS without cutaneous involvement. Despite antifungal and antiviral treatment, the patient’s condition worsened, leading to death. This case highlights the importance of considering neoplastic causes, including KS, in transplant patients with non-resolving pulmonary infiltrates, particularly in the context of prolonged immunosuppression.

Open Respiratory ArchivesVol. 8(1)
Hospital Universitario 12 De Octubre (ES)
Openalex Percentile: Top 56%
Viral-associated cancers and disorders
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