In vitro and in vivo antimutagenic activity of Echinops spinosus crude extract and its aqueous fraction in mouse bone marrow and spleen
High-polar constituents primarily mediated the antimutagenic activity of CEES and AFES. Meanwhile, other phytoconstituents in CEES, such as moderately polar and nonpolar constituents, synergistically potentiated the genoprotective activity, resulting in greater efficacy of CEES than AFES.
Authors
- Maha A. Fahmy (ORCID: https://orcid.org/0000-0002-6772-4295)
- Zeinab M. Hassan (ORCID: https://orcid.org/0000-0003-4917-6843)
- Ayman A. Farghaly (ORCID: https://orcid.org/0000-0001-6082-9361)
- Entesar E. Hassan (ORCID: https://orcid.org/0000-0001-7999-4797)
- Kawthar A. Diab (ORCID: https://orcid.org/0000-0002-3212-3588)
- Emad M. Hassan (ORCID: https://orcid.org/0000-0001-5442-1722)
Institutions
- National Research Centre (EG)
Publication Details
- Journal
- Genes and Environment
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s41021-025-00341-z
- Primary Topic
- Echinoderm biology and ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Centre