Integrated multi-omics identifies GZMA targeting NK cells as a novel therapeutic strategy for hidradenitis suppurativa
Integrative analysis of transcriptomic, MR, and scRNA-seq data strongly implicates GZMA as a potential therapeutic target and highlights the crucial role of NK cells in HS pathogenesis. These findings provide novel insights into HS immunopathology and pave the way for targeted therapeutic development.
Authors
- Jun Yao (ORCID: https://orcid.org/0000-0002-1232-1587)
- M. Ye (ORCID: https://orcid.org/0009-0005-1138-9693)
- Lusheng Miao (ORCID: https://orcid.org/0009-0008-1575-7678)
- Taosheng Miao
Institutions
- Shantou University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Yue Bei People's Hospital (CN)
- Twelfth Guangzhou City People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- SLAS TECHNOLOGY
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.slast.2025.100363
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00