GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral Nociception
These findings identify GPR68 as a key mediator of acid-induced colonic nociception and highlight its potential as a therapeutic target for the treatment of pain in colitis.
Authors
- Javier Aguilera‐Lizarraga (ORCID: https://orcid.org/0000-0002-8135-9933)
- Kyle J. Bednar (ORCID: https://orcid.org/0000-0001-5804-3415)
- Fraser Welsh
- Ewan St. John Smith (ORCID: https://orcid.org/0000-0002-2699-1979)
- James R.F. Hockley (ORCID: https://orcid.org/0000-0002-9578-6071)
- Thomas Pritchard (ORCID: https://orcid.org/0000-0001-7425-4642)
- Gerhard Rogler (ORCID: https://orcid.org/0000-0002-1733-9188)
- Tim Raine (ORCID: https://orcid.org/0000-0002-5855-9873)
- Martin Hausmann (ORCID: https://orcid.org/0000-0002-0696-0251)
- David C. Bulmer (ORCID: https://orcid.org/0000-0002-4703-7877)
- Anne Ritoux
- Luke W Paine (ORCID: https://orcid.org/0009-0009-4099-4648)
- Rohit Gupta (ORCID: https://orcid.org/0000-0003-2958-1526)
- James P. Higham (ORCID: https://orcid.org/0009-0009-5070-0156)
- Samuel Nicholson (ORCID: https://orcid.org/0000-0002-2660-8036)
Institutions
- AstraZeneca (United Kingdom) (GB)
- University of Zurich (CH)
- University of Cambridge (GB)
- Cambridge School (PT)
- Bridge University (SS)
- University Hospital of Zurich (CH)
- AstraZeneca (Australia) (AU)
- AstraZeneca (Switzerland) (CH)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101671
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00