ATG16L1 Regulates Reparative Function of Peritoneal Macrophages During Acute Drug-induced Liver Injury
ATG16L1 activation enhanced peritoneal macrophage phagocytosis and reparative phenotype via autophagy-ROS-MerTK signaling and promoted IL-10-CXCR2-dependent hepatocyte proliferation during DILI. Peritoneal macrophage ATG16L1 might be a novel therapeutic target for DILI.
Authors
- Xun Wang (ORCID: https://orcid.org/0000-0002-7949-3105)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-2348-8163)
- Haoming Zhou (ORCID: https://orcid.org/0000-0003-2778-221X)
- Hao Wang (ORCID: https://orcid.org/0000-0002-0021-7563)
- Ling Lu (ORCID: https://orcid.org/0009-0002-0972-5502)
- Mu Liu (ORCID: https://orcid.org/0000-0002-1202-5673)
- Xinyu Zhan
- Yiyun Gao
Institutions
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101674
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00