High level expression of glucocorticoid receptor (GR) is linked to aggressive tumor features, early biochemical recurrence, and genetic instability in prostate cancer
High level expression of GR is strongly linked to prostate cancer aggressiveness in uni- and multivariate analysis. GR immunohistochemistry - alone or in combination with other markers - holds great potential to identify patients with a high risk for tumor progression.
Authors
- Markus Graefen
- Thorsten Schlomm (ORCID: https://orcid.org/0000-0001-9557-4653)
- Katharina Möller (ORCID: https://orcid.org/0000-0002-9739-4274)
- Maximilian Lennartz (ORCID: https://orcid.org/0000-0002-1572-8200)
- Guido Sauter (ORCID: https://orcid.org/0000-0002-9024-4978)
- Anne Menz (ORCID: https://orcid.org/0000-0002-4364-6464)
- Florian Lutz (ORCID: https://orcid.org/0000-0002-3778-3286)
- Eike Burandt (ORCID: https://orcid.org/0000-0002-5705-9084)
- Andreas Marx (ORCID: https://orcid.org/0000-0002-6471-3689)
- Stefan Steurer (ORCID: https://orcid.org/0000-0002-7199-3615)
- Natalia Gorbokon (ORCID: https://orcid.org/0009-0001-6680-8788)
- Christoph Fraune (ORCID: https://orcid.org/0000-0002-0833-9549)
- Barbara Erber
- Sarah Weinberger (ORCID: https://orcid.org/0000-0002-4259-8990)
- Till Krech
- Andreas M. Luebke (ORCID: https://orcid.org/0000-0003-1464-6964)
- Sarah Jane Pauline Minner (ORCID: https://orcid.org/0000-0003-0765-3568)
- Viktor Reiswich
- Bernhard Ralla (ORCID: https://orcid.org/0000-0001-7226-3852)
- Sören Weidemann (ORCID: https://orcid.org/0000-0001-7037-3265)
- Simon Kind
- Patrick Lebok (ORCID: https://orcid.org/0000-0003-3652-532X)
- Frank Jacobsen (ORCID: https://orcid.org/0009-0009-8047-580X)
- Waldemar Wilczak (ORCID: https://orcid.org/0009-0000-8438-9110)
- Florian Viehweger
- Hans Heinzer (ORCID: https://orcid.org/0000-0003-1326-3750)
- Henning Plage (ORCID: https://orcid.org/0000-0002-7680-1870)
- Nadine Biernath
- Till Sebastian Clauditz (ORCID: https://orcid.org/0000-0002-4257-856X)
- Morton Freytag (ORCID: https://orcid.org/0009-0001-3841-444X)
- Christian Bernreuther (ORCID: https://orcid.org/0000-0003-3939-322X)
- Ronald Simon (ORCID: https://orcid.org/0000-0003-0158-4258)
- Andrea Hinsch (ORCID: https://orcid.org/0000-0001-5868-1185)
- Alexander Haese (ORCID: https://orcid.org/0000-0001-9339-9521)
- Viktoria Chirico
- David Dum (ORCID: https://orcid.org/0000-0002-7884-4313)
- Ria Schlichter
- Neele Heckmann (ORCID: https://orcid.org/0009-0006-7612-3535)
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Martini-Klinik (DE)
- Klinikum Fulda (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Prostate Cancer and Prostatic Diseases
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1038/s41391-025-01046-8
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00