Stereoselective Synthesis of 2-Deoxyglycosides: An Efficient Protocol for Alcohol Deoxygenation
A robust deoxygenation of glycosides to α/β-2-deoxyglycosides is achieved via photocatalytic reductive benzoate cleavage. This operationally simple method features broad functional group tolerance, applying to diverse mono/disaccharide substrates in moderate yields, and is scalable to 5 mmol, offering a practical and efficient synthesis route.
Authors
- Jie Wu (ORCID: https://orcid.org/0000-0002-9865-180X)
- Ying-Wei Wang (ORCID: https://orcid.org/0009-0002-7087-8786)
- Xing-Yong Liang (ORCID: https://orcid.org/0000-0003-0328-6019)
- Lei Wang (ORCID: https://orcid.org/0000-0002-3024-8627)
- Wenqi Zhang (ORCID: https://orcid.org/0000-0003-3525-6308)
- Lu Peng (ORCID: https://orcid.org/0000-0002-8579-5687)
- Xiaonan Liu (ORCID: https://orcid.org/0000-0001-6067-4099)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-3101-8185)
Institutions
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c04094
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00