Role of the PKA–PGC1α–BACE1 Signaling Pathway in Aluminum-Induced Neurotoxicity in PC12 Cells
Exposure to aluminum inhibits the PKA-PGC1α-BACE1 signaling pathway, while PKA agonists can alleviate neurotoxicity by restoring this pathway.
Authors
- William T. Hu (ORCID: https://orcid.org/0000-0003-4862-6777)
- Zhuo-hui Wang
- Xiaoting Lu (ORCID: https://orcid.org/0000-0002-5538-1299)
- Bingqi Pan (ORCID: https://orcid.org/0009-0009-4767-1817)
- Zhong Pei
- Feng‐Ming Kong (ORCID: https://orcid.org/0000-0003-2652-098X)
- Jing Song (ORCID: https://orcid.org/0000-0002-0088-821X)
- Ruonan Wang (ORCID: https://orcid.org/0000-0003-0160-3359)
Institutions
- Shanxi Medical University (CN)
- Ningxia Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1021/acsomega.5c08051
- Primary Topic
- Aluminum toxicity and tolerance in plants and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00