Autoantibody-defined subsets of patients with systemic lupus erythematosus associate with clinical manifestations, NCF2, and HLA DR3-DQ2 genotypes
This study shows how the clinical and serological complexity of SLE is associated with the genetic diversity of HLA and non-HLA regions. We thus suggest further investigation of mechanistic correlates to variations in the NCF2 gene as well as the tight association between DRB3-DQB2 haplotype and anti-SSB production.
Authors
- Henrik Leffers (ORCID: https://orcid.org/0000-0001-5821-2768)
- Niels Steen Krogh (ORCID: https://orcid.org/0000-0002-8520-1674)
- Bent Deleuran (ORCID: https://orcid.org/0000-0002-7079-1587)
- Lina-Marcela Díaz-Gallo (ORCID: https://orcid.org/0000-0002-5688-0102)
- Søren Brunak (ORCID: https://orcid.org/0000-0003-0316-5866)
- Erik Sørensen (ORCID: https://orcid.org/0000-0002-5002-9077)
- Kāri Stefánsson (ORCID: https://orcid.org/0000-0003-1676-864X)
- Saedís Saevarsdóttir (ORCID: https://orcid.org/0000-0001-9392-6184)
- Salome Kristensen (ORCID: https://orcid.org/0000-0001-5812-5234)
- Anne Voss (ORCID: https://orcid.org/0000-0001-6582-2636)
- Michael Schwinn (ORCID: https://orcid.org/0000-0002-6151-369X)
- Asta Linauskas (ORCID: https://orcid.org/0000-0002-2515-444X)
- Ingileif Jónsdóttir (ORCID: https://orcid.org/0000-0001-8339-150X)
- Elisabet Svenungsson (ORCID: https://orcid.org/0000-0003-3396-3244)
- Ole Birger Pedersen (ORCID: https://orcid.org/0000-0003-2312-5976)
- Anne Troldborg (ORCID: https://orcid.org/0000-0002-9501-1268)
- Laura Johnsen (ORCID: https://orcid.org/0000-0002-6531-0857)
- Ada Colic (ORCID: https://orcid.org/0009-0008-7788-1797)
- Sisse Rye Ostrowski (ORCID: https://orcid.org/0000-0001-5288-3851)
- Karina Banasik (ORCID: https://orcid.org/0000-0003-2489-2499)
- Lene Dreyer (ORCID: https://orcid.org/0000-0002-5156-2922)
- Søren Jacobsen (ORCID: https://orcid.org/0000-0002-5654-4993)
- Dag Leonard (ORCID: https://orcid.org/0000-0002-6275-7282)
- Martin Andersen (ORCID: https://orcid.org/0000-0002-6852-9985)
- Christian Erikstrup
- A Sánchez (ORCID: https://orcid.org/0000-0002-2736-1506)
Institutions
- Uppsala University (SE)
- University of Copenhagen (DK)
- deCODE Genetics (Iceland) (IS)
- Karolinska University Hospital (SE)
- University of Iceland (IS)
- Aalborg University Hospital (DK)
- Novo Nordisk Foundation (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Karolinska Institutet (SE)
- North Denmark Region (DK)
- Zealand University Hospital (DK)
- Danish Pain Research Center (DK)
- Danmarks Nationalbank (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Translational research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.trsl.2025.11.001
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gigtforeningen
- Lundbeckfonden
- Novo Nordisk
- Novo Nordisk Fonden