<scp>PIEZO1</scp> ‐Primary Cilia Axis Mediates Compressive Stress‐Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis
The PIEZO1-primary cilia axis mediates stress-induced growth plate degeneration/ossification: stress upregulates PIEZO1, which relies on primary cilia to promote chondrocyte apoptosis and abnormal ossification; cilia disruption alleviates these effects. This provides insights into AIS pathogenesis and identifies PIEZO1/primary cilia as therapeutic targets.
Authors
- Zichen Cui (ORCID: https://orcid.org/0000-0002-7529-6542)
- Xingzhi Jing (ORCID: https://orcid.org/0000-0001-6916-4204)
- Yukun Du (ORCID: https://orcid.org/0000-0003-1261-5638)
- Fushuai Peng
- Jianyi Li (ORCID: https://orcid.org/0000-0002-3520-2281)
- Tao Li (ORCID: https://orcid.org/0000-0002-9165-3239)
- Guanghui Gu
- Fei Chen (ORCID: https://orcid.org/0000-0002-5972-0745)
- Yongming Xi (ORCID: https://orcid.org/0000-0002-2921-0699)
- Yuanyuan Fan
- Han Zhang (ORCID: https://orcid.org/0000-0002-0166-1973)
- Shuqing Chen (ORCID: https://orcid.org/0000-0002-2321-4760)
- Jun Dong (ORCID: https://orcid.org/0000-0002-5626-975X)
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Shandong Mental Health Center (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1002/jsp2.70133
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao University
- Shandong First Medical University