Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa
We conclude that the role of PL membranes in prothrombinase assembly and function is limited to improving the affinity of FXa for FVa and that the M17-FVa complex is likely to be structurally equivalent to human prothrombinase.
Authors
- Fatma Işık Üstok (ORCID: https://orcid.org/0000-0001-7070-4175)
- James A. Huntington (ORCID: https://orcid.org/0000-0003-0076-7204)
Institutions
- University of Cambridge (GB)
- Cambridge School (PT)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.jtha.2025.10.015
- Citations
- 1
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.77