OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis
OCIAD2 drives PDAC progression through binding to IQGAP1, which activates PI3K/AKT pathway; this in turn preserves mitochondrial function and suppresses apoptosis. Our study identifies OCIAD2 as a critical mediator of tumor progression and a potential therapeutic target in PDAC.
Authors
- Jiangqiao Yao
- Lingming Kong (ORCID: https://orcid.org/0000-0001-7474-4844)
- Ziyan Chen (ORCID: https://orcid.org/0000-0002-3650-5532)
- Kejing Ying (ORCID: https://orcid.org/0000-0001-9642-3929)
- Zhenyan Pan
- Gang Chen (ORCID: https://orcid.org/0000-0001-7713-2413)
- Junqing Wang (ORCID: https://orcid.org/0000-0002-9091-9891)
- Ganglian Lin
- Fengyu Shi
- Qiandong Zhu (ORCID: https://orcid.org/0000-0001-8417-0485)
- Xiulin Wu (ORCID: https://orcid.org/0000-0003-4754-9191)
- Haonan Xie (ORCID: https://orcid.org/0000-0001-5623-2845)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1016/j.cellsig.2025.112217
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00