Topical Bicarbonate Therapy to the Spleen Improves Survival in Rats with Severe Intra-Abdominal Sepsis
Topical splenic NaHCO<sub>3</sub> application was associated with improved survival in severe intra-abdominal sepsis by modulating splenic immune function. This novel tactic holds translational potential as a targeted immunomodulatory adjunct during surgical source control.
Authors
- Katherine Marsh (ORCID: https://orcid.org/0000-0003-1927-6210)
- Zequan Yang (ORCID: https://orcid.org/0000-0001-9993-680X)
- Emily P. Rabinovich (ORCID: https://orcid.org/0000-0003-2230-3240)
- Robert G. Sawyer (ORCID: https://orcid.org/0000-0002-8155-2661)
- Radhika Rastogi (ORCID: https://orcid.org/0000-0002-9859-9917)
- Aimee Zhang
Institutions
- Western Michigan University (US)
- University of Virginia Health System (US)
Publication Details
- Journal
- Surgical Infections
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1177/10962964251394205
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00