Molecular and pathological analysis of <i>FOXL2</i> and <i>TERT</i> promoter mutations in adult-type granulosa cell tumors of the ovary: a study of 64 Japanese patients
This is the first study to clearly demonstrate its practical application of <i>FOXL2 in the diagnosis of aGCTs</i>. Application of the molecular analysis to a large aGCT cohort is crucial for understanding true characteristics and establishing novel treatment strategy of this disease.
Authors
- Nozomu Yanaihara (ORCID: https://orcid.org/0000-0003-0160-7085)
- Masataka Takenaka (ORCID: https://orcid.org/0000-0002-3833-4730)
- Yuichi Shoburu (ORCID: https://orcid.org/0000-0001-6533-3234)
- Toshiyuki Seki (ORCID: https://orcid.org/0000-0002-7559-7089)
- Takako Kiyokawa (ORCID: https://orcid.org/0000-0002-7407-6345)
- Kyosuke Yamada (ORCID: https://orcid.org/0000-0002-5216-7297)
- Satoshi Yanagida (ORCID: https://orcid.org/0000-0001-6699-4528)
- Motoaki Saito (ORCID: https://orcid.org/0000-0001-6764-8459)
- Eitaro Suzuki (ORCID: https://orcid.org/0000-0002-9684-8860)
- Daito Noguchi (ORCID: https://orcid.org/0000-0002-3935-9737)
- M. Iwamoto (ORCID: https://orcid.org/0000-0003-3418-5595)
- Aikou Okamoto (ORCID: https://orcid.org/0000-0002-5079-0464)
- Ayako Kawabata (ORCID: https://orcid.org/0000-0001-5220-4409)
- Hirokuni Takano (ORCID: https://orcid.org/0000-0002-6465-7883)
- Ryusuke Kaya (ORCID: https://orcid.org/0009-0002-2938-8822)
- Chie Nagata (ORCID: https://orcid.org/0000-0003-4897-2119)
- M Saito (ORCID: https://orcid.org/0009-0005-5131-8419)
Institutions
- Jikei University School of Medicine (JP)
- Katsushika Medical Center (JP)
- The Jikei University Hospital (JP)
- Jikei University Kashiwa hospital (JP)
- Dokkyo Medical University (JP)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3802/jgo.2026.37.e44
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jikei University School of Medicine