Immunomodulatory effects of bacterial lysates on the IL-17 signaling pathway in an asthma mouse model

OM-85 exerts multi-dimensional immunoregulatory effects in allergic asthma by suppressing IL-17A-mediated signaling and restoring immune homeostasis. These findings suggest that OM-85 may represent a promising immunotherapeutic approach for managing steroid-resistant asthma phenotypes associated with IL-17-driven inflammation.

Authors

Mimi Gao
Xue Wang (ORCID: https://orcid.org/0009-0006-6853-326X)
Xiaoying Wei
Li Yin (ORCID: https://orcid.org/0000-0001-5280-0075)
Fang Li (ORCID: https://orcid.org/0000-0001-5456-0255)

Institutions

Hebei Medical University (CN)
Second Hospital of Hebei Medical University (CN)

Publication Details

Journal: Journal of Asthma
Published: 2025-11-05
DOI: https://doi.org/10.1080/02770903.2025.2581003
Primary Topic: Pediatric health and respiratory diseases
Type: article
Field-Weighted Citation Impact: 0.00

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article

Immunomodulatory effects of bacterial lysates on the IL-17 signaling pathway in an asthma mouse model

Mimi Gao, Xue Wang, Xiaoying Wei, Li Yin et al.

Nov 5, 2025

Journal of Asthma

Pediatric health and respiratory diseases

article

Immunomodulatory effects of bacterial lysates on the IL-17 signaling pathway in an asthma mouse model

Mimi Gao, Xue Wang, Xiaoying Wei, Li Yin, Fang Li

November 5, 2025article en

Abstract

OM-85 exerts multi-dimensional immunoregulatory effects in allergic asthma by suppressing IL-17A-mediated signaling and restoring immune homeostasis. These findings suggest that OM-85 may represent a promising immunotherapeutic approach for managing steroid-resistant asthma phenotypes associated with IL-17-driven inflammation.

Journal of AsthmaVol. 63(2)

Hebei Medical University (CN), Second Hospital of Hebei Medical University (CN)

Openalex Percentile: Top 51%

Pediatric health and respiratory diseases

DOI Source OpenAlex

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Immunomodulatory effects of bacterial lysates on the IL-17 signaling pathway in an asthma mouse model — Mimi Gao, Xue Wang, et al. · Journal of Asthma (2025) | TGRS Research Map | TGRS