Unique Role of Proximal Tubule Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and Na <sup>+</sup> /H <sup>+</sup> Exchanger Isoform 3 Phosphorylation
These findings demonstrate that DPP4 modulates NHE3 activity by preventing pS552-NHE3 accumulation, promoting an anti-natriuretic effect. In the absence of PT DPP4, these mechanisms are disrupted, reducing Ang II sensitivity, maintaining high pS552-NHE3 levels, and likely enhancing pressure-natriuresis, underscoring the role of PT DPP4 in modulating signaling mechanisms governing renal function.
Authors
- Flavia L. Martins (ORCID: https://orcid.org/0000-0002-3115-4526)
- Érika Fernandes de Jesus (ORCID: https://orcid.org/0000-0002-8442-9298)
- Ravi Nistala (ORCID: https://orcid.org/0000-0001-9577-8074)
- Adriana C. C. Girardi (ORCID: https://orcid.org/0000-0003-3715-6917)
- João Carlos Ribeiro-Silva (ORCID: https://orcid.org/0000-0001-6350-2321)
Institutions
- SUNY Upstate Medical University (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- University of Missouri (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1111/apha.70127
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Missouri
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Institutes of Health
- School of Medicine, University of Missouri
- National Institute of Diabetes and Digestive and Kidney Diseases