Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19
Environmental contamination is the primary source of MRSA transmission in ICUs. The agrC-T43I mutation drives ST5 dominance post-pandemic by enhancing biofilm-dependent persistence, underscoring the need for genomic surveillance to guide infection control.
Authors
- Yan Chen (ORCID: https://orcid.org/0000-0002-7679-1713)
- Jiancang Zhou (ORCID: https://orcid.org/0000-0003-0782-3344)
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Yueqin Hong
- Feiteng Zhu
- Xiaoxing Du (ORCID: https://orcid.org/0000-0003-3608-195X)
- Shengnan Jiang (ORCID: https://orcid.org/0000-0001-9973-3404)
- Weiyi Huang (ORCID: https://orcid.org/0009-0002-8155-5093)
- Yiyi Chen (ORCID: https://orcid.org/0000-0003-0947-9102)
- Zhengan Wang (ORCID: https://orcid.org/0000-0002-5579-6523)
- H.L. Ni
- Yeqiong Liu
Institutions
- Sir Run Run Shaw Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1016/j.ijid.2025.108186
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00