TRYBECA-1: A Randomized Phase III Study of Eryaspase Combined With Chemotherapy Versus Chemotherapy as Second-Line Treatment in Patients With Advanced Pancreatic Adenocarcinoma

The addition of eryaspase to chemotherapy did not improve OS, PFS, or ORR. AEs were generally consistent with previous reports of chemotherapy. These results do not support additional development of eryaspase in PDAC.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2025-11-04
DOI
https://doi.org/10.1200/jco-25-00872
Citations
1
Primary Topic
Protein Kinase Regulation and GTPase Signaling
Type
article
Field-Weighted Citation Impact
0.81
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article

TRYBECA-1: A Randomized Phase III Study of Eryaspase Combined With Chemotherapy Versus Chemotherapy as Second-Line Treatment in Patients With Advanced Pancreatic Adenocarcinoma

Jaime Feliú, Roberto Pazo-Cid, Rossana Berardi, Christophe Tournigand et al.
1 citations
Journal of Clinical Oncology
Protein Kinase Regulation and GTPase Signaling
0.81
article

TRYBECA-1: A Randomized Phase III Study of Eryaspase Combined With Chemotherapy Versus Chemotherapy as Second-Line Treatment in Patients With Advanced Pancreatic Adenocarcinoma

Jaime Feliú, Roberto Pazo-Cid, Rossana Berardi, Christophe Tournigand, Iman El‐Hariry, Mariano Ponz‐Sarvisé, Christos Fountzilas, Pieter‐Jan Cuyle, David Tougeron, Miguel Marín, Rocio García‐Carbonero, Yann Molin, Antonio Cubillo Gracián, Isabelle Trouilloud, Marcus Smith Noel, Richard Kay, Jean‐Baptiste Bachet, Harpreet Wasan, Hagop Youssoufian, Pascal Hammel, Bruno Bockorny, Laurent Mineur, Fabio Gelsomino, Tamara Saurí, Olivier Bouché, Jean‐Philippe Metges, Teresa Macarulla, Thierry Lecomte, Manuel M. Hidalgo, Eric Van Cutsem, Rosine Guimbaud, Jean–Luc Van Laethem, Frédéric Forget, Juan José Reina, Fabienne Portales
article en
1 citations

Abstract

The addition of eryaspase to chemotherapy did not improve OS, PFS, or ORR. AEs were generally consistent with previous reports of chemotherapy. These results do not support additional development of eryaspase in PDAC.

Journal of Clinical OncologyVol. 43(35)
Universidad Complutense de Madrid (ES), University of Modena and Reggio Emilia (IT), Marche Polytechnic University (IT), Roswell Park Comprehensive Cancer Center (US), Beth Israel Deaconess Medical Center (US), Université Libre de Bruxelles (BE), Imperial College Healthcare NHS Trust (GB), Georgetown University (US), Breast Cancer Research Foundation (US), Université Paris-Est Créteil (FR), Cornell University (US), Brown University (US), Universitair Ziekenhuis Leuven (BE), Hospital Universitario La Paz (ES), Hammersmith Hospital (GB), MedStar Georgetown University Hospital (US), Université de Poitiers (FR), Sorbonne Université (FR), Research Institute Hospital 12 de Octubre (ES), Hospital Universitario Virgen Macarena (ES), Centre Hospitalier Universitaire de Tours (FR), Assistance Publique – Hôpitaux de Paris (FR), Hospital Universitario 12 De Octubre (ES), Hôpital Saint-Antoine (FR), Hospital La Paz Institute for Health Research (ES), Centre Hospitalier Universitaire de Reims (FR), Ciência Viva (PT), Pitié-Salpêtrière Hospital (FR), HM Hospitales (ES), Hôpital Rangueil (FR), Centre de Recherche en Cancérologie de Lyon (FR), Vall d'Hebron Hospital Universitari (ES), Erytech Pharma (France) (FR), NKT Therapeutics (United States) (US), Clinica Universidad de Navarra (ES), Imelda Hospital (BE), Instituto de Investigación Sanitaria Aragón (ES), Hospital Universitario HM Sanchinarro (ES), Institut de Recherche en Cancérologie de Montpellier (FR), Hospital Universitario Virgen de la Arrixaca (ES), Institut Sainte Catherine (FR), Hôpital Paul-Brousse (FR), Hôpital Maison Blanche (FR), Vall d'Hebron Institute of Oncology (ES), Universidad Autónoma de Madrid (ES), Université de Reims Champagne-Ardenne (FR), KU Leuven (BE)
Openalex Percentile: Top 22%
Protein Kinase Regulation and GTPase Signaling
0.81
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