Diagnostic and Predictive value of Serum Anti C1q Antibody in a sample of Patients with Systemic Lupus Erythematous

Background: Anti C1q antibody is the most studied between antibodies directed against a component of the complement system. AntiC1q antibodies are present in patients with lupus, who often have high clinical disease activity. The aim is to assess Diagnostic and predictive value of serum anti C1q antibody in patients with SLE, to evaluate the correlation between serum anti C1q antibody with sociodemographic and clinical characteristic of SLE patients.Materials and methods: A total of 35 SLE patients and 35 apparently healthy individuals were selected as control group in the current study. Serum level of anti C1q antibody was detected by ELISA technique. This case control study was conducted at the Rheumatology Consultation Clinic of Baghdad Teaching Hospital, kidney Diseases and Transplant Center/ Medical City from January 2020 to September 2020.Results: There was a significant association between Anti C1q antibody and Systemic Lupus Erythematous Disease Activity Index Score. There was no significant association between Anti C1q antibody among patients or controls. There was no significant association between sociodemographic characteristics and anti C1q antibody. For laboratory investigations, there was no significant association with anti C1q antibody. There was no significant association between organ involvement and anti C1q antibody.Conclusion: As associated with SLE disease activity score suggesting its potential usefulness in assessment of disease activity, but not as accurate diagnostic marker, which is still need further elucidation and interpretation.