Transcriptomic Profiling Reveals Differences in Mucosal Defense and Ciliary Gene Expression in Eosinophilic Nasal Polyps Stratified by IgE Levels
Tissue IgE levels delineate clinically and transcriptionally distinct eCRSwNP endotypes. IgE-high nasal polyps demonstrated epithelial barrier dysfunction, mucus overproduction, and antimicrobial peptide activation, highlighting the potential of IgE-based stratification to guide personalized treatment strategies in eCRSwNP.
Authors
- Yuzhuo Liu (ORCID: https://orcid.org/0000-0002-7942-1769)
- Zhenzhen Zhu (ORCID: https://orcid.org/0000-0003-3245-3306)
- Yujie Chen (ORCID: https://orcid.org/0000-0003-0803-3117)
- Weiqing Wang (ORCID: https://orcid.org/0000-0002-9440-1117)
- Wei Lv (ORCID: https://orcid.org/0000-0001-5311-0316)
- Lei Wang (ORCID: https://orcid.org/0000-0001-8686-8764)
- Jinbo Han (ORCID: https://orcid.org/0000-0003-1724-2412)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1002/alr.70048
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University
- China Postdoctoral Science Foundation
- Peking Union Medical College Hospital
- Peking Union Medical College