Denifanstat for moderate‐to‐severe acne: A Phase 2, randomized, double‐blind, placebo‐controlled trial
Denifanstat 50 mg once daily for 12 weeks was generally well tolerated and showed potential to reduce total lesion counts in moderate-to-severe acne vulgaris. Larger and longer term studies are needed to confirm efficacy and safety.
Authors
- Aie Xu (ORCID: https://orcid.org/0000-0001-7255-086X)
- Jinzi J. Wu
- Lunfei Liu (ORCID: https://orcid.org/0000-0003-3200-4279)
- Rixin Chen (ORCID: https://orcid.org/0000-0002-2507-0609)
- Rong Xiao (ORCID: https://orcid.org/0000-0002-6214-8057)
- Leihong Xiang (ORCID: https://orcid.org/0000-0002-2712-3962)
- Liming Wu (ORCID: https://orcid.org/0000-0002-4708-0883)
- Chunlei Zhang (ORCID: https://orcid.org/0000-0003-1685-2198)
- Jinyan Wang
- Yan Lü (ORCID: https://orcid.org/0000-0001-7159-879X)
- He Li (ORCID: https://orcid.org/0000-0003-0924-5891)
- Yanyan Feng
- Xunyi Dai
- Qin‐yi Chen (ORCID: https://orcid.org/0009-0007-4140-8458)
- Yuemei Yan
- Ying Gao (ORCID: https://orcid.org/0000-0002-6000-9336)
Institutions
- Central South University (CN)
- Peking University (CN)
- Fudan University (CN)
- Kunming Medical University (CN)
- The Fourth People's Hospital (CN)
- Ningbo No. 2 Hospital (CN)
- Nanyang Institute of Technology (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Third People's Hospital of Hangzhou (CN)
- Wuxi No.2 People's Hospital (CN)
- Chengdu Second People's Hospital (CN)
- Nanyang Medical College (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Peking University Third Hospital (CN)
- Hangzhou DAC Biotech (China) (CN)
- The First People's Hospital of Guiyang (CN)
- Central Hospital of Wuhan (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Second Xiangya Hospital of Central South University (CN)
- Huashan Hospital (CN)
- Ningbo No.6 Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1111/jdv.70119
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00