Distinct strategies of epithelial cell barrier disruption by Leptospira interrogans isolated from human patients in Okinawa, Japan
Our findings suggest that the maintenance of epithelial barrier integrity requires both the afadin-F-actin and α-catenin-F-actin links, and that Oki53 and Oki65 employ distinct strategies to disrupt the AJ-F-actin link and, thus, the epithelial barrier.
Authors
- Claudia Toma (ORCID: https://orcid.org/0000-0002-9852-1722)
- Tetsu Yamashiro (ORCID: https://orcid.org/0000-0002-8458-3287)
- Isabel Sebastián (ORCID: https://orcid.org/0000-0002-9265-6829)
- Tetsuya Kakita (ORCID: https://orcid.org/0000-0002-8991-7397)
- Hunter Barbee
Institutions
- University of the Ryukyus (JP)
- Okinawa Prefectural Institute of Health and Environment (JP)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1371/journal.pntd.0013693
- Primary Topic
- Leptospirosis research and findings
- Type
- article
- Field-Weighted Citation Impact
- 0.00