Effect of dopamine on TGF-β2 secretion by human retinal pigment epithelial cells and the underlying mechanism
Our findings suggest that dopamine suppresses TGF-β2 secretion in human retinal pigment epithelial cells primarily through activation of D2 receptors, which appears to involve the YAP-TGF-β-Smad signaling pathway. This regulatory mechanism may contribute to the control of scleral remodeling and thus influence the development of myopia.
Authors
- He Jin (ORCID: https://orcid.org/0000-0002-3475-5677)
- Tao Meng (ORCID: https://orcid.org/0000-0002-7390-3601)
- Zheng Liu (ORCID: https://orcid.org/0000-0001-5391-1105)
- Zhixiang Ding (ORCID: https://orcid.org/0000-0001-8573-8730)
- Jing Fan (ORCID: https://orcid.org/0000-0002-1919-3354)
- Binbin Yang (ORCID: https://orcid.org/0000-0002-7514-2981)
- Qiujin Zhang
Institutions
- Guilin Medical University (CN)
- Taihe Hospital (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
- Affiliated Hospital of Guilin Medical College (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1371/journal.pone.0335526
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00