Cryptococcus neoformans and PLWH: the role of serum cryptococcal antigen screening

CrAg positivity may be detected during the asymptomatic phase of cryptococcal infection. Although current guidelines recommend serum CrAg screening for individuals with CD4+ T cell counts below 100 cells/µL, the detection of positive results in those with CD4+ T cell counts above this threshold should also be carefully evaluated, considering the possibility of false-positive or false-negative results.

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Publication Details

Journal
The Journal of Infection in Developing Countries
Published
2025-10-31
DOI
https://doi.org/10.3855/jidc.21389
Primary Topic
Fungal Infections and Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Cryptococcus neoformans and PLWH: the role of serum cryptococcal antigen screening

Özlem Gül, Ceren Atasoy Tahtasakal, Okan Derin, Dilek Yıldız Sevgi et al.
The Journal of Infection in Developing Countries
Fungal Infections and Studies
article

Cryptococcus neoformans and PLWH: the role of serum cryptococcal antigen screening

Özlem Gül, Ceren Atasoy Tahtasakal, Okan Derin, Dilek Yıldız Sevgi, Ahsen Öncül, Ayşe Barış, Nazife Duygu Demirbaş, İlyas Dökmetaş
article en

Abstract

CrAg positivity may be detected during the asymptomatic phase of cryptococcal infection. Although current guidelines recommend serum CrAg screening for individuals with CD4+ T cell counts below 100 cells/µL, the detection of positive results in those with CD4+ T cell counts above this threshold should also be carefully evaluated, considering the possibility of false-positive or false-negative results.

The Journal of Infection in Developing CountriesVol. 19(10)
Sağlık Bilimleri Üniversitesi (TR), Şişli Etfal Eğitim ve Araştırma Hastanesi (TR), University of Health Sciences Antigua (AG)
Openalex Percentile: Top 57%
Fungal Infections and Studies
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