Connective tissue changes in Ehlers–Danlos syndromes with and without axial spondyloarthropathy

Co-occurring SpA poses diagnostic challenges due to its clinical overlap with EDS. The increased thoracolumbar fascia thickness observed in SpA + EDS patients, while also present to a lesser degree in EDS-only participants, suggests that fascial remodeling may reflect overlapping inflammatory and mechanical processes. Ultrasonography may thus serve as a complementary tool to monitor connective tissue changes in this population.