Association between Multisite and Site-specific Chronic Pain, Analgesic Use, Metabolic–Proteomic Profile, and Incident Chronic Kidney Disease in Diabetes
Multisite chronic pain and opioid use are associated with elevated CKD risk in diabetes, supported by metabolomic/proteomic signatures. These findings highlight the need for renal-conscious pain management in diabetes care.
Authors
- Xiaoqin Gan (ORCID: https://orcid.org/0009-0002-1906-666X)
- Sheng Nie (ORCID: https://orcid.org/0000-0002-8267-7909)
- Xianhui Qin (ORCID: https://orcid.org/0000-0001-7812-7982)
- Fan Fan Hou (ORCID: https://orcid.org/0000-0003-3117-7418)
- Yiting Wu (ORCID: https://orcid.org/0000-0001-8079-9497)
- Ziliang Ye (ORCID: https://orcid.org/0000-0001-8314-6977)
- Sisi Yang (ORCID: https://orcid.org/0009-0008-2696-9107)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0002-9894-248X)
- Yu Huang (ORCID: https://orcid.org/0000-0003-2560-5674)
- Yiwei Zhang (ORCID: https://orcid.org/0000-0001-9611-9337)
- Yanjun Zhang (ORCID: https://orcid.org/0000-0003-2176-6657)
- Hao Xiang (ORCID: https://orcid.org/0000-0003-4823-2890)
Institutions
- Feminist Archive North (GB)
- Guangzhou Experimental Station (CN)
- Key Laboratory of Guangdong Province (CN)
- National Clinical Research (US)
- Southern Medical University (CN)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1097/aln.0000000000005829
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00