Human adenosine deaminase type 2 deficiency enhances NK cell activation but impairs maturation and function
NK cells, or natural killer cells, might be interesting players to investigate further in the disease process of patients with deficiency of ADA2, a rare, recently discovered inborn error of immunity.
Authors
- Bethany Pillay (ORCID: https://orcid.org/0000-0001-7964-544X)
- Nele Berghmans (ORCID: https://orcid.org/0009-0003-9217-6459)
- Leen Moens (ORCID: https://orcid.org/0000-0002-5347-6526)
- Eline Bernaerts (ORCID: https://orcid.org/0000-0002-7998-4553)
- Isabelle Meyts (ORCID: https://orcid.org/0000-0003-1214-0302)
- Marjon Wouters (ORCID: https://orcid.org/0000-0002-4675-1665)
- Patrick Matthys (ORCID: https://orcid.org/0000-0002-9685-6836)
- Jarne Beliën (ORCID: https://orcid.org/0000-0001-6731-6649)
- Tania Mitera
- Amber De Visscher (ORCID: https://orcid.org/0000-0002-9577-2390)
- Verena Kienapfel (ORCID: https://orcid.org/0009-0002-5476-2257)
- Bénédicte Dubois (ORCID: https://orcid.org/0000-0003-0604-8702)
Institutions
- Allen Institute for Brain Science (US)
- Rega Institute for Medical Research (BE)
- Bipar (FR)
- Immune Regulation (United Kingdom) (GB)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1172/jci196381
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering