A rebrand for proteasome inhibition in solid tumors via continuous hepatic artery infusion
Targeting tumors with proteosome inhibitors has demonstrated antitumor activity and has been successfully translated to the clinic for patients with multiple myeloma. However, in patients with solid tumors, treatment with proteosome inhibitors as single agents has consistently failed to yield meaningful responses. In our study, we investigate the potential of hepatic artery infusion pump delivery of carfilzomib, to continuously direct a large dose to the tumor with least hepatic toxicity.
Authors
- Priyanka P. Desai (ORCID: https://orcid.org/0009-0002-3376-3226)
- Emily C. Smith (ORCID: https://orcid.org/0000-0002-5078-6748)
- David E. Kleiner (ORCID: https://orcid.org/0000-0003-3442-4453)
- H. Stepp
- Keith Thomas Schmidt (ORCID: https://orcid.org/0009-0008-0285-0216)
- Surajit Sinha (ORCID: https://orcid.org/0000-0002-7204-2248)
- Lindsay R. Friedman (ORCID: https://orcid.org/0000-0002-6226-4816)
- Kirsten Remmert (ORCID: https://orcid.org/0009-0004-0668-4164)
- Nicole Russell (ORCID: https://orcid.org/0000-0003-2571-7406)
- Robynne Ashe
- Jason Ho (ORCID: https://orcid.org/0000-0001-6951-282X)
- Tracey Pu (ORCID: https://orcid.org/0000-0001-7880-2183)
- Jack H. Victory (ORCID: https://orcid.org/0000-0003-1845-6658)
- Michael B. Yaffe (ORCID: https://orcid.org/0000-0002-9547-3251)
- William D. Figg (ORCID: https://orcid.org/0000-0003-2428-5613)
- Jessica Burke
- Jonathan M. Hernandez
- Alyssa V. Eade (ORCID: https://orcid.org/0009-0009-8354-0881)
- Carolina M. Larrain (ORCID: https://orcid.org/0009-0009-4773-2632)
Institutions
- National Institutes of Health (US)
- Office of the Director (US)
- Anesthesiology and Surgical Oncology Research Group (US)
- National Cancer Institute (US)
- Spanish Oncology Genitourinary Group (ES)
- Department of Health and Human Services (US)
Publication Details
- Journal
- JCI Insight
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1172/jci.insight.199200
- Citations
- 1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute