[¹⁸F]Fluspidine PET/CT imaging to assess postoperative pain-associated σ1 receptor expression in female rats under analgesia
PET/CT imaging with [<sup>18</sup>F]fluspidine sensitively detects pain-associated σ1R expression post-liver resection. Necessary analgesia interferes with some behavioral tests, limiting their reliability for pain assessment. [<sup>18</sup>F]Fluspidine detects peripheral σ1R upregulation despite non-steroidal anti-inflammatory drug analgesia. Imaging pain-associated receptors provides valuable insights for refining preclinical pain monitoring.
Authors
- Pascal Paschenda
- René H. Tolba (ORCID: https://orcid.org/0000-0002-0383-3994)
- K. E. Becker
- Felix Manuel Mottaghy (ORCID: https://orcid.org/0000-0002-7212-6521)
- Andreas Hartmann (ORCID: https://orcid.org/0000-0002-0335-984X)
- Fabian M. Kiessling (ORCID: https://orcid.org/0000-0002-7341-0399)
- Masoud Sadeghzadeh (ORCID: https://orcid.org/0000-0002-6844-6637)
- Rupert Palme (ORCID: https://orcid.org/0000-0001-9466-3662)
- Anne Rix (ORCID: https://orcid.org/0000-0003-2624-046X)
- Renée Michèle Girbig
- Alexandru Florea (ORCID: https://orcid.org/0000-0002-2076-0723)
- Wenjia Liu
- Jasmin Baier (ORCID: https://orcid.org/0000-0002-4597-1041)
- Leonie Tix
Institutions
- University of Veterinary Medicine Vienna (AT)
- Maastricht University (NL)
- Maastro Clinic (NL)
- RWTH Aachen University (DE)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s41747-025-00646-2
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft