Zhichuanling oral liquid attenuates airway inflammation in asthma by targeting the STIM1/CHOP/JNK axis
ZCLOL alleviates airway inflammation and hyperresponsiveness in asthma by restoring Ca<sup>2+</sup> homeostasis and suppressing ERS through inhibition of the STIM1/CHOP/JNK axis. These findings provide mechanistic evidence supporting ZCLOL as a potential multi-target therapeutic strategy for asthma.
Authors
- Liping Sun (ORCID: https://orcid.org/0000-0002-3679-4469)
- Jiaqi Wu
- Huidan Chen (ORCID: https://orcid.org/0009-0003-3839-7904)
- Shkarenkova Lv
- Shengmei Xu
- Yue Li (ORCID: https://orcid.org/0000-0002-7945-0359)
- Jinpu Zhu (ORCID: https://orcid.org/0009-0005-8513-2073)
- Yilong Zhu (ORCID: https://orcid.org/0000-0003-3924-9324)
- Shijie Xing (ORCID: https://orcid.org/0000-0001-9733-3407)
- Yang Xia (ORCID: https://orcid.org/0000-0003-3990-2792)
- Zhongtian Wang (ORCID: https://orcid.org/0000-0003-3417-9865)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Yanbian University (CN)
- Changchun Institute of Optics, Fine Mechanics and Physics (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Changchun Institute of Applied Chemistry (CN)
- Foshan Maternity and Child Health Care Hospital (CN)
- Changchun University of Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1016/j.jep.2025.120859
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00