Developing interferon-β as a safe in vivo experimental-medicine model of human inflammation
IFN-β is a safe, robust new experimental model of mild inflammation that can be safely used to induce transient changes in systemic inflammation in healthy individuals from 18-75 years. Modulation of diverse immunological processes suggests it could be a valuable new experimental medicine tool across neuropsychiatric and neurodegenerative disorders.
Authors
- Kathy Triantafilou (ORCID: https://orcid.org/0000-0002-7473-6278)
- Claire MacIver (ORCID: https://orcid.org/0000-0002-5040-3487)
- Simon A. Jones (ORCID: https://orcid.org/0000-0001-7297-9711)
- Barbara Szomolay (ORCID: https://orcid.org/0000-0002-5375-5533)
- Claudia Bone
- Neil Andrew Harrison (ORCID: https://orcid.org/0000-0002-9584-3769)
- Helena Leach
- Eva Periche-Tomas (ORCID: https://orcid.org/0000-0002-3909-9875)
- Jonathan Underwood (ORCID: https://orcid.org/0000-0001-6963-2821)
- Carol Guy (ORCID: https://orcid.org/0000-0002-1629-7385)
Institutions
- Cardiff University (GB)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1016/j.bbi.2025.106173
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Medical Research Council