Integrated multi-omics and causal inference framework with experimental validation reveals key drivers of air pollution–induced acute kidney injury
This study provides novel mechanistic insights into air pollution-induced AKI by identifying key genes, pathways, and susceptible renal cell types. The integrative framework combining multi-omics, causal inference, and experimental validation establishes a robust foundation for future translational research and therapeutic development targeting environmentally driven kidney injury.
Authors
- Liangmin Fu (ORCID: https://orcid.org/0000-0001-8038-4742)
- Yinhuai Wang (ORCID: https://orcid.org/0000-0003-4731-0252)
- Zhichao Huang
- Zebin Deng (ORCID: https://orcid.org/0000-0001-9509-211X)
- Jiachen Liu (ORCID: https://orcid.org/0000-0002-0263-3704)
- Fei Deng (ORCID: https://orcid.org/0000-0002-1997-4572)
- Dianjie Zeng (ORCID: https://orcid.org/0009-0006-4803-0833)
Institutions
- Central South University (CN)
- Zen-Noh (Japan) (JP)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Ministry of Education and Child Care (CA)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1097/js9.0000000000003742
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00