The joint impact of elevated homocysteine and type 2 diabetes on non-healing wounds and all-cause mortality: integrated clinical and multi-omics analyses
T2D and HHcy synergistically worsen non-healing wounds, but not all-cause mortality. In diabetic males, Hcy levels displayed a J-shaped relationship with non-healing wound risk. Mechanistically, Hcy amplified systemic inflammation and drove stromal-immune crosstalk via the MIF-CD74/CXCR4 axis, reshaping the diabetic wound microenvironment.
Authors
- Xiaohang Xie
- Yichuan Li (ORCID: https://orcid.org/0009-0003-9346-3791)
- Yuyang Zeng (ORCID: https://orcid.org/0000-0003-0593-4542)
- Ying Wang (ORCID: https://orcid.org/0000-0002-1819-294X)
- Qi Zhang (ORCID: https://orcid.org/0009-0000-1799-6252)
- Qin L (ORCID: https://orcid.org/0000-0002-1754-7083)
- Heao Zhang
- Yong Zhang (ORCID: https://orcid.org/0000-0002-5945-9970)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1097/js9.0000000000003715
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00