Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like–phosphatidylinositol 3-kinase–protein kinase B signaling axis
Exosomal miR-20b-5p represses MASTL, remodels PI3K-AKT, and attenuates Ara-C responses in AML models. Seed-mutant reporters and 3'-UTR-independent rescue support target specificity. Findings are mechanistic and hypothesis-generating; clinical relevance requires confirmation in primary blasts and prospective validation.
Authors
- Wei Cheng (ORCID: https://orcid.org/0000-0002-4526-7900)
- Bingqing Cheng (ORCID: https://orcid.org/0000-0001-6298-9406)
- Aoshuang Huang
- Jin‐Hui Yang (ORCID: https://orcid.org/0000-0001-8373-0620)
- Hai Jun Guo
- Ya Li (ORCID: https://orcid.org/0000-0003-4356-7042)
- Ying Chen (ORCID: https://orcid.org/0000-0001-9758-7116)
- Zihao Zhao (ORCID: https://orcid.org/0000-0001-7497-3276)
- Weiwei Cheng (ORCID: https://orcid.org/0000-0002-4907-7872)
- Xue Zou
- Jiumei Cai
- Jishi Wang (ORCID: https://orcid.org/0000-0003-1946-8087)
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- International Journal of Biological Macromolecules
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1016/j.ijbiomac.2025.148750
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00