The association between CD14 (C-159T) single-nucleotide polymorphism and Behcet’s syndrome and its clinical manifestations in Egyptian patients, an observational case–control genetic association study

CD14 (C-159T) polymorphism is associated with an increased risk of developing Behcet's syndrome and is correlated with its dermatological manifestations. Key points • Behcet's syndrome is a variable-vessel vasculitis in which aberrant innate immunity is integral to the pathogenesis of the disease. • CD14 molecules recognize pathogens with subsequent activation of innate immunity. • The CD14 promoter gene C-159T single-nucleotide polymorphism increases the susceptibility to Behcet's syndrome. • The C-159T polymorphism correlates with skin manifestations of Behcet's syndrome.