Systemic and local antimicrobial strategies to prevent Periprosthetic joint infection
Further reductions in the incidence of PJI through antimicrobial strategies will require: (1) the adoption of alternative trial designs such as registry-nested and adaptive platform trials to study outcomes with low event rates; (2) improved adherence to established best practices, particularly in systemic antibiotic prophylaxis; (3) precision prevention informed by validated risk stratification tools; and (4) novel interventions targeting emerging biological mechanisms such as the gut microbiome.
Authors
- Paul C. Jutte (ORCID: https://orcid.org/0000-0002-6022-2807)
- Àlex Soriano (ORCID: https://orcid.org/0000-0002-9374-0811)
- Wierd P Zijlstra (ORCID: https://orcid.org/0000-0001-6410-3824)
- Sung Il Yoon
- Marjan Wouthuyzen‐Bakker (ORCID: https://orcid.org/0000-0001-7866-2467)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Medisch Centrum Leeuwarden (NL)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Expert Review of Anti-infective Therapy
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/14787210.2025.2586067
- Citations
- 1
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01