Exploring the Link Between Stress-Induced Naive T-Cells and Esophageal Squamous Cell Carcinoma Risk: A Multi-Omics Investigation
Our integrative analysis establishes naïve T-cell abundance as a novel causal risk factor for esophageal squamous cell carcinoma, mediated through metabolic silencing and differentiation blockade within the tumor niche. These findings redefine the immunopathogenic paradigm of esophageal carcinogenesis, suggesting that therapeutic strategies targeting T-cell metabolic reprogramming may disrupt immune-evasion pathways. The demonstrated synergy between population-level genetic inference and single-cell mechanistic validation provides a transformative framework for cancer immunology research.
Authors
- Longyu Zhu
- Hao Xu (ORCID: https://orcid.org/0000-0001-5827-1821)
- Yishuai Li (ORCID: https://orcid.org/0000-0003-4425-366X)
- Jingge Cheng
- Dengfeng Zhang (ORCID: https://orcid.org/0000-0002-0777-5859)
- Hong‐Ye Zhao (ORCID: https://orcid.org/0000-0002-5900-3033)
- Ping Zhu (ORCID: https://orcid.org/0000-0002-5608-9070)
Institutions
- Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1245/s10434-025-18541-w
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gujarat Council on Science and Technology