Patterns and Correlates of Initiation of Long-Acting Injectable Cabotegravir for Preexposure Prophylaxis: A Case-Control Analysis
We conducted a case-control analysis to evaluate the determinants for initiating long-acting injectable cabotegravir (LACAB) as preexposure prophylaxis (PrEP) in a real-world setting with limited drug access. Individuals selected for LACAB experienced more side effects from oral PrEP, riskier sexual behavior, longer prior PrEP use, and a significantly higher incidence of STIs during follow-up. Despite this, LACAB was well tolerated, and discontinuation rates were low. Our findings support prioritizing LACAB for individuals most exposed to HIV and with low adherence to oral regimens, especially in contexts where logistical or economic constraints limit universal access to PrEP.
Authors
- G Cavazza
- Massimo Puoti (ORCID: https://orcid.org/0000-0003-3278-7138)
- Roberto Rossotti (ORCID: https://orcid.org/0000-0003-4965-8789)
- Giorgio Burastero (ORCID: https://orcid.org/0000-0002-3746-3098)
- Nicholas Brian Bana (ORCID: https://orcid.org/0009-0009-6467-3697)
- Chiara Baiguera
- Elena Di Gennaro (ORCID: https://orcid.org/0000-0001-6223-7845)
- Leonardo Francesco Rezzonico (ORCID: https://orcid.org/0000-0002-5271-3956)
- Giovanna Travi (ORCID: https://orcid.org/0000-0002-4206-0066)
- Livio Luzi (ORCID: https://orcid.org/0000-0003-3183-0552)
- Marco Merli (ORCID: https://orcid.org/0000-0001-5081-8669)
- Enrico Caruso (ORCID: https://orcid.org/0009-0004-7626-4704)
Institutions
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Check Point (Israel) (IL)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Sexually Transmitted Diseases
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1097/olq.0000000000002272
- Citations
- 1
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 1.40