Association of Tumor-Infiltrating Lymphocytes (TILs) With Pathological Complete Response to Neoadjuvant Therapy in Breast Cancer
High stromal TILs were strongly associated with improved pathological complete response following neoadjuvant therapy, particularly in HER2-positive and triple-negative breast cancer subtypes. Routine TIL assessment offers a simple, cost-effective, and clinically meaningful biomarker for predicting therapeutic response and guiding individualized treatment strategies, especially within resource-limited regional settings.
Authors
- Sauid Ishaq (ORCID: https://orcid.org/0000-0003-1458-4708)
- Sudhair Abbas Bangash
- Kamran Chaudhry
- Muhammad Khurrum Islam
- Quratulain Badar
- Noor ul Ain (ORCID: https://orcid.org/0000-0002-5118-8109)
- Tanveer Adil (ORCID: https://orcid.org/0009-0001-5707-1702)
Institutions
- King Edward Medical University (PK)
- Sarhad University of Science and Information Technology (PK)
- Allied Hospital (PK)
- Jinnah Sindh Medical University (PK)
- Ziauddin Hospital (PK)
- Mayo Hospital (PK)
Publication Details
- Journal
- Cureus
- Published
- 2025-11-04
- DOI
- https://doi.org/10.7759/cureus.96076
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00