Stereoselective Decarboxylative <i>C</i> -Alkenylation of Anomeric Glycosyl Carboxylic Acids through Cobalt–Photoredox Dual Catalysis
Alkenyl C-glycosides hold significant value across diverse applications, yet their synthetic methodologies remain underdeveloped. Particularly, the simultaneous precise control of the anomeric selectivity and the geometry of the double bond poses a formidable synthetic challenge. Herein, we report that the use of a cost-effective and nontoxic cobaloxime complex enables a dual anomeric and Z/E-stereoselective photocatalytic synthesis of alkenyl C-glycosides from simple and stable glycosyl carboxylic acids and terminal alkenes.
Authors
- Wei Zhao (ORCID: https://orcid.org/0000-0001-7298-238X)
- Mingxiang Zhu (ORCID: https://orcid.org/0000-0002-8817-988X)
- Samir Messaoudi (ORCID: https://orcid.org/0000-0002-4994-9001)
- Fang Zhang (ORCID: https://orcid.org/0000-0002-9656-8893)
- Huiying Chen (ORCID: https://orcid.org/0000-0002-3894-3050)
- Jinyang Hai
Institutions
- Ministry of Education of the People's Republic of China (CN)
- École Polytechnique (FR)
- Shanghai Normal University (CN)
- Laboratoire de Synthèse Organique (FR)
- Institut Polytechnique de Paris (FR)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1021/acscatal.5c06029
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94