Hypoxia Alters Corneal Circadian Rhythms and Disrupts Epithelial, Neural, and Immune Balance
Hypoxia drives model-specific and circadian phase-dependent reprogramming of corneal transcriptomic rhythms, resulting in coordinated structural and immune dysfunction. Identifying ZT18 and ZT3 as critical phases highlights the potential for chronotherapeutic interventions in hypoxia-related ocular surface disorders.
Authors
- Jiangman Liu
- Dingli Lu (ORCID: https://orcid.org/0000-0002-0061-7604)
- Yipeng Jing (ORCID: https://orcid.org/0000-0002-4534-3125)
- Zhijie Li (ORCID: https://orcid.org/0000-0002-3186-144X)
- Jiaxin Wu
Institutions
- Jinan University (CN)
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Henan Provincial Eye Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1167/iovs.66.14.5
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China