CuI/TEMPO-mediated aerobic oxidative sp <sup>3</sup> C–H functionalization affording pyrrol-2-one derivatives
5-Hydroxy-1<i>H</i>-pyrrol-2-ones represent a very important class of compounds. However, their syntheses rely on precursors that are exotic and commercially unavailable, or on multistep operations. A cascade reaction can evade multistep syntheses, but most substrates are not amenable to cascade strategies. We thoughtfully designed a cascade strategy, choosing the Knoevenagel product of a ketone and malononitrile as a very trivial starting material. This strategy afforded 5-hydroxy-1<i>H</i>-pyrrol-2-ones <i>via</i> a cascade of C(sp<sup>3</sup>)-H functionalization, directed nitrile hydrolysis and C-N bond-forming reactions.
Authors
- Tanmoy Dutta (ORCID: https://orcid.org/0000-0003-3669-5433)
- Saikat Khamarui (ORCID: https://orcid.org/0000-0001-6785-0227)
- Bholanath Maity (ORCID: https://orcid.org/0000-0001-5969-0112)
- Souvik Mondal (ORCID: https://orcid.org/0000-0001-5531-9105)
- Abhijit Hazra (ORCID: https://orcid.org/0000-0003-1094-549X)
- S.K. Mandal (ORCID: https://orcid.org/0000-0002-0207-7226)
- Suman Ray (ORCID: https://orcid.org/0000-0001-7153-0381)
- Aritra Mondal (ORCID: https://orcid.org/0009-0002-0902-2938)
- Paramita Das (ORCID: https://orcid.org/0000-0003-4078-3639)
Institutions
- Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
- Presidency University (IN)
- KPC Medical College and Hospital (IN)
- King Abdullah University of Science and Technology (SA)
- University of Kalyani (IN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01297j
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00